个人简介：

本人为浙江大学生物信息学博士，研究方向聚焦于病原菌系统生物学与精准肿瘤学，致力于开发前沿AI算法以解决关键生物医学问题。已在该领域取得系列研究成果，在Communications Biology、Nucleic Acids Research、mSystems等权威期刊上发表论文30余篇，其中以第一/共同第一或通讯作者发表13篇，谷歌学术H指数13。现拥有国家发明专利2项。积极参与学术共同体建设，担任Advanced Science、Computational and Structural Biotechnology Journal等高水平期刊审稿人，并受邀出任Frontiers in Bioinformatics客座编辑。

教育背景：

2006.09-2010.07 理学学士，生物科学，安徽师范大学

2010.09-2013.06 理学硕士，生化与分子生物学，深圳大学,导师：郑易之教授

2021.09-2025.06 理学博士，生物信息学，浙江大学，导师：陈铭教授

工作经历：

2014.04-2020.08 研究助理，深圳大学医学院

2020.09-2021.08 研究助理，深圳湾实验室

2025.07-至今 阜阳师范大学

科研项目：

1. 阜阳师范大学2025年博士科研启动项目（2025KYQD0131），基于深度学习的细菌IV型分泌系统效应蛋白鉴定与分类研究，2025-10至2027年10，9万，主持

2. 国家重点研发计划政府间国际科技创新合作重点专项（2023YFE0112300）：抗癌肽CIGB-552调控网络的分子机制及抗菌肽药靶系统挖掘与应用研究，2023-12至2026-12, 200万元，骨干成员

3. 国家自然科学基金国际合作项目（32261133526）：基于ANDSystem与多组学的水稻和小麦胁迫响应分子调控网络及智能作物平台（Smart Crop）的构建，2023-01至2025-12，105万，参与

4. 国家自然科学基金项目（32270709）：基于bulk和单细胞转录组挖掘水稻lncRNA参与调控非生物胁迫响应机制的研究，2023-01至2025-12，54万，参与

5. 深圳市科创委(JCYJ20160307115221141)，III型分泌系统毒性效应蛋白SteA的转运机制分析，2017-01至2018-12，30万元，已结题，参与

代表性论文：

1.Yueming Hu^§, Zewei Chen^§, Akosiererem S. Sokaribo^§, Ziyi Zhao^§, Junya Zhang, Shuhong Liu, Runhong Chen, Yuping Deng, Hongxia Bao, Xinjie Hui, Ming-an Sun, Guo-Qiang Zhu, Shu-Lin Liu, Aaron P. White, Yejun Wang*. Evolution of Salmonella Chromosomes and Its Influence on Gene Expression and Chromosomal Conformation. (submitted toMolecular Biology and Evolution)

2.Yueming Hu^§, Minqing Yan^§, Yanyan Zhu, Haoyu Chao, Sida Li, Qinyang Ni,Yanshi Hu, Enyan Liu, Liya Liu, Yifan Chen, Zeya Zhou, Yuhao Chen, Shilong Zhang, Yejun Wang, Cong Feng, Ming Chen*. Improved Prediction of Bacterial Type VI Secretion Effector Proteins Using an Integrated Convolutional Neural Network Model Combining N-terminal signal sequences, Evolutionary Information and pre-trained protein language Features. (submitted tomSystems)

3. Kaiwen Fang^§, Yifei Lu^§, Cong Feng, Shilong Zhang, Sida Li,Yueming Hu^*, Ming Chen^*.AGEncRNA: a database of age-associated non-coding RNAs. (submitted toDatabase)

4.Yueming Hu^§, Liya Liu^§, Yanyan Zhu^§, Enyan Liu, Haoyu Chao, Sida Li, Cong Feng, Yanshi Hu, Yuhao Chen, Shilong Zhang, Yifan Chen, Luyao Xie, Zixuan Wang, Liangwei Wu, Yejun Wang, Ming Chen*. HPInet: Interpretable prediction of Host-Pathogen protein–protein Interactions using a transformer-based neural network. (submitted toBriefings In Bioinformatics)

5. Kun Wu^§,Yueming Hu^§, Qingyang Ni, Liang Xu, Ming Chen, Haoxuan Liu. An Adaptive Deep Learning framework for high-resolution prediction of somatic mutations in normal and cancer-associated cells. (submitted toNature Machine Intelligence)

6. Yanyan Zhu^§, Liya Liu^§,Yueming Hu^§, Sida Li, Enyan Liu, Ming Chen*. InTxDB: interaction data between gram-negative bacteria secreted effectors and host proteins. (submitted toDatabase)

7.Yueming Hu^§, Yejun Wang^§, Xiaotian Hu, Haoyu Chao, Sida Li, Qinyang Ni, Yanyan Zhu, Yixue Hu, Ziyi Zhao, Ming Chen*. T4SEpp: A pipeline integrating protein language models to predict bacterial type IV secreted effectors.Comput Struct Biotechnol J. 2024 Jan 23:23:801-812. (中科院大类二区，JCR Q1，IF₅=6.3，IF₂=6.0)

8. Ziyi Zhao^§, Yixue Hu^§,Yueming Hu, Aaron P White, Yejun Wang*. Features and algorithms: facilitating investigation of secreted effectors in Gram-negative bacteria.Trends Microbiol. 2023 Nov;31(11):1162-1178. (中科院一区TOP期刊，JCR Q1，IF₅=18.6，IF₂=15.9)

9. Haoyu Chao^§, Shilong Zhang^§,Yueming Hu^§, Qingyang Ni^§, Saige Xin, Liang Zhao, Vladimir A Ivanisenko, Yuriy L Orlov, Ming Chen*. Integrating Omics Databases for Enhanced Crop Plant Breeding.J Integr Bioinform. 2023 Jul 25;20(4):20230012. (中科院三区，IF₅= 3.0，IF₂=1.5)

10. Haoyu Chao^§,Yueming Hu^§, Liang Zhao, Saige Xin, Qingyang Ni, Peijing Zhang, Ming Chen. Biogenesis, Functions, Interactions, and Resources of Non-Coding RNAs in Plants.Int J Mol Sci. 2022 Mar 28;23(7):3695. (中科院大类二区TOP期刊，JCR Q1，IF₅= 6.2，IF₂=5.6)

11.Yueming Hu^§, Xing-Sheng Shu^§, Jiaxian Yu^§, Ming-an Sun, Zewei Chen, Xianming Liu, Qiongfang Fang, Wei Zhang, Xinjie Hui, Ying Ying, Li Fu, Desheng Lu, Rakesh Kumar, Yejun Wang*. Improving the diversity of captured full-length isoforms using a normalized single-molecule RNA sequencing method.Communications Biology. 2020 July 30;3(403). doi: 10.1038/s42003-020-01125-7 (中科院一区TOP期刊；贡献-三代RNA测序建库方法开发、组学数据分析、胃癌转录组数据分析，JCR Q1，IF₅= 6.3，IF₂=6.3)

12. Jiaxian Yu^§,Yueming Hu^§, Yafei Xu^§, Shengping Zhang, Jue Wang, Jianlin Shao, Dianjing Guo*, Yejun Wang*. LUADpp: an effective prediction model on prognosis of lung adenocarcinomas based on somatic mutational features.BMC Cancer.2019 Mar 22;19(1):263. doi: 10.1186/s12885-019-5433-7 (中科院二区TOP期刊；贡献–肿瘤预后遗传特征鉴定、机器学习模型开发，JCR Q2，IF₅= 3.4，IF₂=3.2)

13.Yueming Hu^§, He Huang^§, Xi Cheng, Xingsheng Shu, Aaron P. White, John Stavrinides, Wolfgang Köster, Guoqiang Zhu, Zhendong Zhao, Yejun Wang*. A global survey of bacterial type III secretion systems and their effectors.Environ Microbiol.2017 Oct;19(10):3879-3895. doi: 10.1111/1462-2920.13755 (生态学科中科院一区TOP期刊、微生物学经典期刊；贡献–细菌比较基因组、进化基因组、数据库，JCR Q1，IF₅= 6.0，IF₂=5.4)

14.Yueming Hu^§, He Huang^§, Xinjie Hui, Xi Cheng, Aaron P. White, Zhendong Zhao, Yejun Wang*. Distribution and evolution of Yersinia leucine rich repeat proteins.Infect Immun.2016 Jul 21; 84(8):2243-54. doi: 10.1128/IAI.00324-16 (美国微生物学会经典期刊、中科院二区TOP；贡献–提出和验证细菌基因进化新理论、比较基因组、进化研究，JCR Q2，IF₅= 3.8，IF₂=3.6)

教学工作：

承担本科生《中学生物学实验及实验教学研究》等课程

社会工作：

担任Advanced Science、Advanced Intelligent Systems、Comput Struct Biotechnol J等期刊审稿人，担任Frontiers in Bioinformatics客座编辑。