个人简介:
杨宸,华南农业大学博士,香港大学深圳医院博士后,主要研究方向为环境暴露精子小RNA的改变对子代发育的影响、精子变形过程以及胚胎着床于蜕膜化。
教育背景:
2010.09 -2014.06,本科,北京农学院,动物科学专业,获学士学位
2014.09-2017.06,硕士研究生,安徽农业大学,动物遗传育种与繁殖专业,导师:方富贵
2017.09-2021.06,博士研究生,华南农业大学,基础兽医学专业,导师:杨增明
工作经历:
2021.06-2024.05博士后,香港大学深圳医院,导师:杨树标,段永刚
2024.12-至今 讲师, 阜阳师范大学
科研项目:
1.白细胞精子症中CCR6-CCL20轴调控免疫细胞活化及其对精子损伤的机制研究,广东省自然科学基金(参与)。
代表性论文:
1. Yang C, Li J, Liu JC, Zeng Q, Yeung WS, Chiu PC, Duan YG. Alterations of small non-coding RNA in the spermatozoa of mice with paternal experimental autoimmune epididymo-orchitis are associated with metabolic dysfunction in offspring. Andrology. 2023 Dec 21. doi: 10.1111/andr.13579. Epub ahead of print. PMID: 38127116.
2. Yang C, Zeng QX, Liu JC, Yeung WS, Zhang JV, Duan YG. Role of small RNAs harbored by sperm in embryonic development and offspring phenotype. Andrology. 2023 May;11(4):770-782. doi: 10.1111/andr.13347. Epub 2022 Dec 2. PMID: 36417503.
3. Yang C, Li Y, Pan HY, Li MY, Pan JM, Chen ST, Zhang HY, Yang ZS, Dou HT, Yang ZM. Female reproductive abnormalities in mouse adolescent pregnancy. Reproduction. 2021 Oct 5;162(5):353-365. doi: 10.1530/REP-21-0240. PMID: 34486978.
4. Chen Yang, Jing Ye, Xiumei Li, Xiaoxiao Gao, Kaifa Zhang, Lei Luo, Jianping Ding, Yunhai Zhang, Yunsheng Li, Hongguo Cao, Yinghui Ling, Xiaorong Zhang, Ya Liu, Fugui Fang. DNA methylation patterns in the hypothalamus of female pubertal goats. PLOS ONE. 2016. 11(10): e0165327.
5. C Yang, J Ye, Y Liu, J Ding, H Liu, X Gao, X Li, Y Zhang, J Zhou, X Zhang, W Huang, F Fang, Y Ling. Methylation pattern variation between goats and rats during the onset of puberty. Reprod Domest Anim. 2018 Jun;53(3):793-800.
6. Chen Yang, Xiaoxiao Gao, Jing Ye, Jianping Ding, Ya Liu, Hongyu Liu, Xiumei Li, Yunhai Zhang, Jie Zhou, Weiping Huang, Fugui Fang, Yinghui Ling. The interaction between DNA methylation and long non-coding RNA during the onset of puberty in goats. Reprod Domest Anim. 2018 Dec;53(6):1287-1297
7. Liu JC, Wang P, Zeng QX, Yang C, Lyu M, Li Y, Yeung WS, Chiu PC, Haidl G, Allam JP, Duan YG. Myd88 Signaling Is Involved in the Inflammatory Response in LPS-Induced Mouse Epididymitis and Bone-Marrow-Derived Dendritic Cells. Int J Mol Sci. 2023 Apr 25;24(9):7838. doi: 10.3390/ijms24097838. PMID: 37175545; PMCID: PMC10178089.
8. Gong J, Wang P, Liu JC, Li J, Zeng QX, Yang C, Li Y, Yu D, Cao D, Duan YG. Integrative Analysis of Small RNA and mRNA Expression Profiles Identifies Signatures Associated With Chronic Epididymitis. Front Immunol. 2022 May 11;13:883803. doi: 10.3389/fimmu.2022.883803. PMID: 35634321; PMCID: PMC9130659.
9. Liu W, Chen J, Yang C, Lee KF, Lee YL, Chiu PC, Zhang Y, Duan YG, Liu K, Yeung WS. Expression of microRNA let-7 in cleavage embryos modulates cell fate determination and formation of mouse blastocysts†. Biol Reprod. 2022 Dec 10;107(6):1452-1463. doi: 10.1093/biolre/ioac181. PMID: 36136742.
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