刘 祥

发布日期:2025-02-25    浏览次数:

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   硕士生导师、教授、博士;手机:13891690861E-mailliuxiang888525@163.com


刘祥,男,1983年生,教授,博士,硕士生导师,中山大学生化与分子专业博士,西北农林科技大学兽医学博士后,德国柏林自由大学访学,安徽省生物化学与分子生物学学会理事,主要从事动物疫苗、药物制剂研究。主持科技部高端外国专家项目1项,主持省科技厅重点研发、面上项目各1项,主持安徽省高校协同创新项目1项,主持教育厅项目3项、校级项目4项、横向项目2项。参与国家高技术研究发展(863)计划、国家自然科学基金、国家高端外专局项目、陕西省科技厅重点研发、陕西省科技创新团队等项目8项。以第一作者/通讯作者在VaccinesJ Proteome ResInt J Mol SciFish Shellfish Immun等国内外知名期刊上发表论文40余篇,其中SCI收录20余篇。VaccinesApplied Microbiology and BiotechnologyInternational Journal of Biological MacromoleculesJournal of Medicinal FoodJournal of Cellular Biochemistry等期刊审稿人。申请国家发明专利3项,参与出版专著2部;获校级优秀硕士生导师、优秀科技工作者、优秀本科生指导教师、优秀班主任称号,校讲课大赛二等奖。指导研究生获国家奖学金3人次,校优秀毕业论文、校优秀毕业生各1次;指导本科生获国家级大学生创新创业项目1项、省级3项,指导本科生获大学生挑战杯科技论文竞赛省二等奖1次。


1)承担主要的科研项目:

2023年安徽省高校协同创新项目:绿色无抗养殖OmpA蛋白免疫制剂的生物合成与开发利用(GXXT-2023-077),主持,100万元,在研。

2021年省科技厅自然科技基金面上项目:基于表位疫苗技术的奶山羊乳房炎多价疫苗的合成及免疫机制研究(2022JM-120),主持,10万元,已结题。

2022年省教育厅重点项目:基于表位疫苗技术的奶山羊乳腺炎多价疫苗设计重塑、生物合成与免疫活性研究(2022AH051330),主持,10万元,在研。

2018年科技部国家外国专家局项目:秦岭特色生物资源开发利用关键技术研究与示范(GDT20186100426),主持,32万元,已结题。

2016年省科技厅重点研发项目:奶牛乳房炎三联重组表位多肽疫苗的研发(2016NY-088),主持,15万元,已结题。

2017年省教育厅科学研究计划项目:奶牛乳房炎三联表位多肽疫苗的研制及免疫保护功能研究(17JK0137),主持,3万元,已结题。

2021年市校合作项目:秦巴中药在水产养殖病原菌防治中的应用及其免疫机制研究(SXJ-2104),主持,20万元,已结题。

2013年省教育厅科学研究计划项目:骨硬化蛋白在股骨头坏死症中的作用研究(2013JK0723),主持,2万元,已结题。


2)代表性的科研论文:

Liu Xiang, Peng Xuanxian, Li Hui. Escherichia coli activate extraintestinal antibody response and provide anti-infective immunity. International Journal of Molecular Sciences, 2024, 25: 7450. (SCI二区)

Liu Xiang*, Xiao Huihui, Cui Pan, et al. Differential polyvalent passive immune protection of egg yolk antibodies (IgY) against live and inactivated Vibrio fluvialis in fish. Fish and Shellfish Immunology, 2024, 151: 109751. (SCI二区Top)

Liu Xiang*, Chao Jia, Xiao Huihui, et al. Identification of polyvalent passive vaccine candidates from egg yolk antibodies (IgY) of important outer membrane proteins of Aeromonas hydrophila in fish. Aquaculture Reports, 2024, 35: 102002. (SCI二区Top)

Xiao Huihui, Cui Pan…....Liu Xiang*. A comparison of polyvalent passive immunoprotection from antibodies with different immunity models of live or inactivated Vibrio fluvialis in fish. Fishes, 2024, 9, 302. (SCI三区,通讯作者)

Sijie Jian, Wei Sun, Chao Jia, Liu Xiang*, Chen Chen*. The immune response and passive protective abilities of the outer membrane lipoprotein Slp of Aeromonas hydrophila against the major pathogenic bacteria of freshwater aquaculture in fish. Pakistan Journal of Zoology, 2024, 56(2): 889-877. (SCI四区,通讯作者)

Liu Xiang*, Xiao Huihui, Chao Jia, et al. Polyvalent passive vaccine candidates from egg yolk antibodies (IgY) of important outer membrane proteins (PF1380 and ExbB) of Pseudomonas fluorescens in fish. Fish and Shellfish Immunology, 2023, 143: 109211. (SCI二区Top)

Xiang Liu, Yuhao Nie, Rui Chen, et al. Inhibitory activities of extracts from Chinese medicinal herbs on a-amylase, a-glucosidase, and pancreatic lipase. Pharmacognosy Magazine, 2023, 19(3): 530-538. (SCI四区)

Liu Xiang*, Rong Na, Sun Wei, et al. The identification of polyvalent protective immunogens and immune abilities from the outer membrane proteins of Aeromonas hydrophila in fish. Fish and Shellfish Immunology, 2022, 128: 101-112. (SCI二区Top)

Liu Xiang*, Sun Wei, Jian Sijie, et al. Passive protective ability of the outer membrane protein PF1380 of Pseudomonas fluorescens against the major pathogenic bacteria of freshwater aquaculture in fish. Aquaculture Reports, 2022, 22: 100985. (SCI二区Top)

Liu Xiang*, Sun Wei, Jian Sijie, et al. Synthesis of Escherichia coli OmpA oral nanoparticles and evaluation of immune functions against the major etiologic agent of cow mastitis. Vaccines, 2021, 9: 304. (SCI二区)

Sun Wei, Rong Na……Liu Xiang*. Immune responses and protective efficacy of outer membrane protein ExbB of Pseudomonas fluorescens against Aeromonas hydrophila and Pseudomonas fluorescens affecting Carassius auratus. Aquaculture International, 2021, 29:2823-2840. (SCI三区, 通讯作者)

Liu Xiang, Chen Chen, Zhang Xiaoying. Drug–drug interaction of acetaminophen and roxithromycin with the cocktail of cytochrome P450 and hepatotoxicity in rats. International Journal of Medical Sciences, 2020, 17: 414-421. (SCI三区)

Xu Long, Liu Xiang*, Chen Chen, et al. Determination of dehydroepiandrosterone in dietary supplements and pharmaceutical products by a competitive chemiluminescent enzyme immunoassay. Analytical Letters, 2020, 3: 842-853. (SCI四区, 通讯作者)

Chen Chen……Liu Xiang*, Zhang Xiaoying*. Immunoprotective evaluation of Escherichia coli outer membrane protein A against the main pathogens of animal mastitis. Tropical Journal of Pharmaceutical Research January, 2020, 19 (1): 155-162. (SCI四区, 通讯作者)

Chen Chen……Liu Xiang*, Zhang Xiaoying*. Purification and characterization of lysozyme from Chinese Lueyang black-bone Silky fowl egg white. Preparative Biochemistry & Biotechnology, 2019, 49(3): 215-221. (SCI四区, 通讯作者)

Chen Chen……Zhang Xiaoying, Liu Xiang*. Evaluation of immunogenicity, protective immunity on aquaculture pathogenic Vibrio and fermentation of Vibrio alginolyticus flagellin FlaC protein. Iranian Journal of Biotechnology, 2019, 17(3): e2628. (SCI四区, 通讯作者)

Liu Xiang, Yang Manjun, Wang Shengnan, et al. Difffferential antibody responses to outer membrane proteins contribute to difffferential immune protections between live and inactivated Vibrio parahemolyticus. Journal of Proteome Research, 2018, 17: 2987-2994. (SCI二区)

Chen Chen……Liu Xiang*, Zhang Xiaoying*. Purification and characterization of an antimicrobial protein from Gastrodia elata Blume tubers. Tropical Journal of Pharmaceutical Research, 2018, 17(9): 1717-1723. (SCI四区, 通讯作者)

Liu Xiang*, Chen Chunlin, Chen Chen, et al. Construction of a recombinant OmpC dominant epitope based vaccine against Escherichia coli and evaluation of its immunogenicity and protective immunity. Jundishapur Journal of Microbiology, 2017, 10(11):e55652. (SCI四区)

Liu Xiang*, Chen Chunlin, Chen Chen, et al. Construction and evaluation of a novel triple cell epitope based polypeptide vaccine against cow mastitis induced by Staphylococcus aureus, Escherichia coli and Streptococcus. Tropical Journal of Pharmaceutical Research, 2017, 16 (10): 2477-2486. (SCI四区)

21. Liu Xiang, She Xintao, Zhu Qingfeng, et al. Heterogeneous interactome between Litopenaeus vannameiplasma proteins and Vibrio parahaemolyticus outer membrane proteins. Fish Shellfish Immunology, 2013, 34: 192-198. (SCI一区)